Adenosine in the Thymus

Frontiers in Pharmacology

Gergely Joós¹  Krisztina Köröskényi¹  Zsuzsa Szondy¹ 

[1] Department of Basic Medical Sciences of Dental Faculty, University of Debrecen, Debrecen, Hungary;Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary;

关键词: efferocytosis;    adenosine;    thymocyte;    apoptosis;    T cell selection;   

DOI  :  10.3389/fphar.2017.00932

来源: DOAJ

【 摘 要 】

Adenosine is an ancient extracellular signaling molecule that regulates various biological functions via activating four G-protein-coupled receptors, A1, A2A, A2B, and A3 adenosine receptors. As such, several studies have highlighted a role for adenosine signaling in affecting the T cell development in the thymus. Recent studies indicate that adenosine is produced in the context of apoptotic thymocyte clearance. This review critically discusses the involvement of adenosine and its receptors in the complex interplay that exists between the developing thymocytes and the thymic macrophages which engulf the apoptotic cells. This crosstalk contributes to the effective and immunologically silent removal of apoptotic thymocytes, as well as affects the TCR-driven T-cell selection processes.

【 授权许可】

Unknown