Factors Affect the Eradication Rate of Helicobacter pylori by Modified Quadruple Therapy: A Prospective Cohort Study

Infection and Drug Resistance

关键词: helicobacter pylori;    25-hydroxyvitamin d;    eradication rate;    irregular medication;   

DOI  :  

来源: DOAJ

【 摘 要 】

Qiao-Li Lan, Hao-Yue Sun, Yi Ye, Ying Wang, Ya Liu, Xue-Jian Weng Department of Digestive System, Wenzhou People’s Hospital, The Third Affiliated Hospital of Shanghai University, The Wenzhou Third Clinical College of Wenzhou Medical University, Wenzhou, 325000, People’s Republic of ChinaCorrespondence: Ying Wang, Department of Digestive System, Wenzhou People’s Hospital, The Third Affiliated Hospital of Shanghai University, The Wenzhou Third Clinical College of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People’s Republic of China, Tel [phone], Fax [phone], Email [e-mail]: This study aimed to investigate related factors affecting the eradication rate of Helicobacter pylori (Hp) by modified quadruple therapy.Methods: Between September 2020 and March 2021, 341 patients who were diagnosed with Hp infection and whose infections were confirmed by gastroscopy, a histological examination, and a C13-UBT without culturing and antimicrobial susceptibility studies received a two-week anti-Hp treatment, a modified quadruple therapy, in our department. The result of C13-UBT was rechecked 4 weeks after the drug withdrawal, and the patients were divided into two groups—a success group and a failure group—according to the final breath result. The general clinical information and related laboratory indexes of each patient were collected, and the factors affecting the eradication rate were analyzed.Results: The total clinical eradication rate was 80.06% (273/341), and the failure rate was 19.94% (68/341), correspondingly. Univariate analysis identified statistically significant differences between the two groups in serum 25-hydroxyvitamin D levels, presence of oral diseases, positive cytotoxin-associated gene A (CagA), and medical compliance (P < 0.05). Meanwhile, the use of a proton pump inhibitor (PPIs) and antibiotics was statistically different (P < 0.05). Logistic regression analysis revealed that vitamin D level (< 20 ng/mL) [OR = 98.56, 95% CI (29.01– 334.83), P < 0.001] and medical compliance [OR = 148.18, 95% CI (37.64– 583.33), P < 0.001] were independent effecting factors for eradication rate.Conclusion: Serum 25-hydroxyvitamin D level lower than 20 ng/mL may affect the success of eradication of Hp and is an independent risk factor for eradication failure.Keywords: Helicobacter pylori, 25-hydroxyvitamin D, eradication rate, irregular medication

【 授权许可】

Unknown