Effect of Fermented Red Ginseng Concentrate Intake on Stool Characteristic, Biochemical Parameters, and Gut Microbiota in Elderly Korean Women

Nutrients

Songhee Lee¹  Sunghee Hyun¹  Yeongju Lee¹  Youngsook Park²  Sunghee Jung³  Heesang You⁴  Hyunkoo Lee⁵ 

[1] Department of Biomedical Laboratory Science, Graduate School, Eulji University, Uijeongbu-si 11759, Korea;Department of Gastroenterology, Nowon Eulji University Hospital, Eulji University School of Medicine, Seoul 01830, Korea;Department of Internal Medicine, College of Medicine, Eulji University, Daejeon-si 35233, Korea;Department of Senior Healthcare, Graduate School, Eulji University, Uijeongbu-si 11759, Korea;LHK Fermentation Lab., Seongnam-si 13209, Korea;

关键词: bowel movements;    elderly individual;    fermented red ginseng concentrate;    glucose;    gut microbiota;   

DOI  :  10.3390/nu14091693

来源: DOAJ

【 摘 要 】

Fermented red ginseng (FRG) has been used as a general stimulant and herbal medicine for health promotion in Asia for thousands of years. Few studies have investigated the effects of FRG containing prebiotics on the gut microbiota. Here, 29 Korean women aged ≥ 50 years were administered FRG for three weeks to determine its effect on stool characteristics, biochemical parameters, and gut microbiome. Gut microbial DNA was subjected to 16S rRNA V3–V4 region sequencing to assess microbial distribution in different stages. Additionally, the stool consistency, frequency of bowel movements, and biochemical parameters of blood were evaluated. We found that FRG intake improved stool consistency and increased the frequency of bowel movements compared to before intake. Biochemical parameters such as glucose, triglyceride, cholesterol, low-density lipoprotein cholesterol, creatinine, alkaline phosphatase, and lactate dehydrogenase decreased and high-density lipoprotein cholesterol increased with FRG intake. Gut microbiome analysis revealed 20 specific bacteria after three weeks of FRG intake. Additionally, 16 pathways correlated with the 20 specific bacteria were enhanced after red ginseng intake. In conclusion, FRG promoted health in elderly women by lowering blood glucose levels and improving bowel movement frequency. The increase in bacteria observed with FRG ingestion supports these findings.

【 授权许可】

Unknown