Fluorinated vs. Zwitterionic-Polymer Grafted Surfaces for Adhesion Prevention of the Fungal Pathogen Candida albicans

Polymers

Arianna Tavanti¹  Noemi Poma²  Ilenia Fiaschi²  Elena Masotti²  Fabio Di Francesco²  Andrea Bonini²  Giancarlo Galli²  Elisa Guazzelli²  Elisa Martinelli²  Federico Vivaldi²  Antonella Glisenti³ 

[1] Dipartimento di Biologia, Università di Pisa, 56126 Pisa, Italy;Dipartimento di Chimica e Chimica Industriale and UdR Pisa INSTM, Università di Pisa, 56124 Pisa, Italy;Dipartimento di Scienze Chimiche, Università di Padova, 35131 Padova, Italy;

关键词: candida albicans;    zwitterionic polymer;    fluorinated polymer;    biofouling;    antifouling;    adhesion;   

DOI  :  10.3390/polym12020398

来源: DOAJ

【 摘 要 】

Fluorinated (F6) and zwitterionic, as well as phosphorylcholine (MPC) and sulfobetaine (MSA), copolymers containing a low amount (1 and 5 mol%) of 3-(trimethoxysilyl)propyl methacrylate (PTMSi) were prepared and covalently grafted to glass slides by using the trimethoxysilyl groups as anchorage points. Glass-surface functionalization and polymer-film stability upon immersion in water were proven by contact angle and angle-resolved X-ray photoelectron spectroscopy (AR-XPS) measurements. Antifouling performance of the grafted films was assayed against the yeast Candida albicans, the most common Candida species, which causes over 80% of candidiasis. Results revealed that the F6 fluorinated, hydrophobic copolymers performed much better in reducing the adhesion of C. albicans, with respect to both corresponding zwitterionic, hydrophilic MPC and MSA counterparts, and were similar to the glass negative control, which is well-known to inhibit the adhesion of C. albicans. A composition-dependent activity was also found, with the films of copolymer with 99 mol% F6 fluorinated co-units performing best.

【 授权许可】

Unknown