Non-significant association between − 330 T/G polymorphism in interleukin-2 gene and chronic periodontitis: findings from a meta-analysis

BMC Oral Health

Alessandro Luiz Araújo Bentes Leal¹  Reyce Santos Koga¹  Silvânia da Conceição Furtado¹  Marcelo Diniz Carvalho²  Felipe Rodolfo Pereira da Silva³  José Fernando Marques Barcellos³  Nayana Yared Batista³  Daniel Fernando Pereira Vasconcelos⁴  Juliana Gomes Galeno⁴ 

[1] Department of Morphology, Federal University of Amazonas;Department of Periodontology, Amazonas State University;Doctorate Post-Graduation Program in Basic and Applied Immunology, Federal University of Amazonas;Laboratory of Histological Analysis and Preparation (LAPHIS), Federal University of Piaui;

关键词: Periodontal disease;    Cytokine;    Odds ratio;    Risk factor;    Allele;   

DOI  :  10.1186/s12903-020-1034-8

来源: DOAJ

【 摘 要 】

Abstract Background Chronic periodontitis (CP) is an immune-inflammatory disease that promotes tissue damage around the teeth. Among the several inflammatory mediators that orchestrate the periodontitis, there is the interleukin (IL)-2. Genetic variations in IL2 gene may be associated with the risk and severity of the disease. Contrary results are available in the literature with inconclusive findings and none meta-analysis to gather these data. Methods A literature search was performed for studies published before June 11, 2019 in diverse scientific and educational databases. The data was extracted by two investigators and the statistical evaluation was performed by Review Manager statistical program with heterogeneity (I2) and Odds Ratio (OR) with 95% of Confidence Intervals (CI) calculations and a sensitive analysis to assess the accuracy of the obtained results. The publication bias was evaluated by Begg’ and Egger’s test with Comprehensive meta-analysis software. The value of P < 0.05 was considered as significant. Results Five studies were identified in diverse ethnical groups with 1425 participants. The − 330 T/G polymorphism in IL2 gene was not significantly associated with CP in allelic evaluation (P > 0.05) as well as in the genotypic comparisons (P = 0.15). The Begg’s test and the linear regression Egger’s test did not show any evidence of publication bias risk (P > 0.05) which was corroborated by the absence of obvious asymmetry in Funnel plot graphic. Conclusions This meta-analysis showed a non-significant association between − 330 T/G polymorphism in IL2 gene and CP in any allelic evaluation.

【 授权许可】

Unknown