Carbohydrates in Human Milk and Body Composition of Term Infants during the First 12 Months of Lactation

Nutrients

Alethea Rea¹  LeighC. Ward²  WanJun Tie³  Zoya Gridneva³  ChingTat Lai³  PeterE. Hartmann³  Sambavi Kugananthan³  DonnaT. Geddes³  Kevin Murray⁴ 

[1] Centre for Applied Statistics, The University of Western Australia, Crawley, Perth, WA 6009, Australia;School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia;School of Molecular Sciences, M310, The University of Western Australia, Crawley, Perth, WA 6009, Australia;School of Population and Global Health, The University of Western Australia, Crawley, Perth, WA 6009, Australia;

关键词: human milk carbohydrates;    lactose;    oligosaccharides;    infant;    body composition;    lactation;    daily intake;    breastfeeding frequency;    milk intake;   

DOI  :  10.3390/nu11071472

来源: DOAJ

【 摘 要 】

Human milk (HM) carbohydrates may affect infant appetite regulation, breastfeeding patterns, and body composition (BC). We investigated relationships between concentrations/calculated daily intakes (CDI) of HM carbohydrates in first year postpartum and maternal/term infant BC, as well as breastfeeding parameters. BC of dyads (n = 20) was determined at 2, 5, 9, and/or 12 months postpartum using ultrasound skinfolds (infants) and bioelectrical impedance spectroscopy (infants/mothers). Breastfeeding frequency, 24-h milk intake and total carbohydrates (TCH) and lactose were measured to calculate HM oligosaccharides (HMO) concentration and CDI of carbohydrates. Statistical analysis used linear regression/mixed effects models; results were adjusted for multiple comparisons. Higher TCH concentrations were associated with greater infant length, weight, fat-free mass (FFM), and FFM index (FFMI), and decreased fat mass (FM), FM index (FMI), %FM and FM/FFM ratio. Higher HMO concentrations were associated with greater infant FFM and FFMI, and decreased FMI, %FM, and FM/FFM ratio. Higher TCH CDI were associated with greater FM, FMI, %FM, and FM/FFM ratio, and decreased infant FFMI. Higher lactose CDI were associated with greater FM, FMI, %FM, and FM/FFM, ratio and decreased FFMI. Concentrations and intakes of HM carbohydrates differentially influence development of infant BC in the first 12 months postpartum, and may potentially influence risk of later obesity via modulation of BC.

【 授权许可】

Unknown