A light-activatable antibiotic with high activation efficiency and uncompromised bactericidal potency in the activated state

Journal of Leather Science and Engineering

Gaofu Yang¹  Yi Chen¹  Zhonghui Wang¹  Qi Zeng¹  Delong Hou¹  Rui Wang¹  Zhou Xu² 

[1] College of Biomass Science and Engineering, Sichuan University;School of Life Science and Food Engineering, Yibin University;

关键词: Antibiotic;    Light;    Activatable;    Ciprofloxacin;    Collagen;    Biomaterials;   

DOI  :  10.1186/s42825-021-00051-6

来源: DOAJ

【 摘 要 】

Abstract Achieving activatable antibiotics represents one promising solution to tackle the occurrence of side effects, one major issue now plaguing antibiotic usage in collagen-based biomaterials. Despite considerable effort, however, rationale design of activatable antibiotics that display high activation efficiency and uncompromised bactericidal potency in the activated state remains difficult. Here, we demonstrate a design principle that helps to address this challenge. This strategy differs from previous attempts by underscoring photolytic removal of a functionality directly conjugated to the pharmacophore of an antibiotic, enabling not only an activation efficiency significantly improved beyond previous light-activatable antibiotics, but also bactericidal activity in the activated state as potent as the parent drug. Graphical abstract

【 授权许可】

Unknown