Silicon Photonic Biosensors Using Label-Free Detection

Sensors

DanielM. Ratner¹  Enxiao Luan²  Hossam Shoman²  Lukas Chrostowski²  KarenC. Cheung² 

[1] Department of Bioengineering, University of Washington, 3720 15th Ave. NE, Seattle, WA 98195-5061, USA;Department of Electrical and Computer Engineering, University of British Columbia, 2329 West Mall, Vancouver, BC V6T 1Z4, Canada;

关键词: silicon photonics;    evanescent optical field sensor;    label-free SOI biosensor;    Mach–Zehnder interferometer;    ring resonator;    photonic crystal;    Bragg grating;    sub-wavelength grating;    lab-on-a-chip;    microfluidics;   

DOI  :  10.3390/s18103519

来源: DOAJ

【 摘 要 】

Thanks to advanced semiconductor microfabrication technology, chip-scale integration and miniaturization of lab-on-a-chip components, silicon-based optical biosensors have made significant progress for the purpose of point-of-care diagnosis. In this review, we provide an overview of the state-of-the-art in evanescent field biosensing technologies including interferometer, microcavity, photonic crystal, and Bragg grating waveguide-based sensors. Their sensing mechanisms and sensor performances, as well as real biomarkers for label-free detection, are exhibited and compared. We also review the development of chip-level integration for lab-on-a-chip photonic sensing platforms, which consist of the optical sensing device, flow delivery system, optical input and readout equipment. At last, some advanced system-level complementary metal-oxide semiconductor (CMOS) chip packaging examples are presented, indicating the commercialization potential for the low cost, high yield, portable biosensing platform leveraging CMOS processes.

【 授权许可】

Unknown