Aspergillus fumigatus during COPD exacerbation: a pair-matched retrospective study

BMC Pulmonary Medicine

Jin Jin¹  Hongtao Xu²  Xunliang Tong³  Yimeng Yang⁴  Yanming Li⁵  Sainan Zhu⁵  Anqi Cheng⁶ 

[1] National Clinical Research Center for Respiratory Diseases;WHO Collaborating Centre for Tobacco Cessation and Respiratory Diseases Prevention;Department of Geriatrics, Beijing Hospital, National Center of Gerontology;Department of Laboratory Medicine, Beijing Hospital;Department of Respiratory and Critical Care Medicine, Beijing Hospital;Tobacco Medicine and Tobacco Cessation Centre, Center of Respiratory Medicine, China-Japan Friendship Hospital;

关键词: COPD;    Aspergillus fumigatus;    Fungal colonization;   

DOI  :  10.1186/s12890-018-0611-y

来源: DOAJ

【 摘 要 】

Abstract Background Recently awareness of the importance of Aspergillus colonization in the airway of patients with chronic obstructive pulmonary disease (COPD) was rising. The aim of this study was to investigate the clinical features and short-term outcomes of COPD patients with Aspergillus colonization during acute exacerbation. Methods A pair-matched retrospective study on patients presenting with COPD exacerbation was conducted from January 2014 to March 2016 in Beijing Hospital, China. Results Twenty-three patients with Aspergillus colonization and 69 patients as controls, diagnosed of COPD exacerbation, were included in this study at a pair-matched ratio of 1:3. In stable stage, the percentage of patients with high-dose corticosteroids inhalation in the Aspergillus colonization group is higher than that of in control group (65.5% vs 33.3%, p = 0.048). Multivariate analysis showed that corticosteroids use was the risk factor for isolation of Aspergillus. In acute exacerbation stage, patients in Aspergillus colonization group received higher dose of inhaled corticosteroids and more types of antibiotics than control group. The short-time outcome hinted that the remission time and the duration of hospitalization were longer in the Aspergillus colonization group than in the control group (remission time: 11 ± 4 days vs 7 ± 4 days, p = 0.001; duration: 15 ± 5 days vs 12 ± 4 days, p = 0.011). Conclusions Aspergillus colonization in the lower respiratory tract of COPD patients showed typical clinical manifestations, affected their short time outcome and provided a dilemma of clinical treatment strategy.

【 授权许可】

Unknown