Recent Advances on DNAzyme-Based Biosensors for Detection of Uranyl

Frontiers in Chemistry

Yunlong Bai¹  Lei Zhou¹  Guoping Jiang¹  Lechang Xu¹  Guangyao Zhang²  Huining Chai³ 

[1] Beijing Research Institute of Chemical Engineering and Metallurgy, China National Nuclear Corporation, Beijing, China;Intelligent Wearable Engineering Research Center of Qingdao, Research Center for Intelligent and Wearable Technology, College of Textiles and Clothing, State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao, China;School of Environmental and Municipal Engineering, Qingdao University of Technology, Qingdao, China;

关键词: uranyl sensor;    DNAzyme;    environmental monitoring;    detection;    spectrum;    electrochemistry;   

DOI  :  10.3389/fchem.2022.882250

来源: DOAJ

【 摘 要 】

Nuclear facilities are widely used in fields such as national defense, industry, scientific research, and medicine, which play a huge role in military and civilian use. However, in the process of widespread application of nuclear technology, uranium and its compounds with high carcinogenic and biologically toxic cause a lot of environmental problems, such as pollutions of water, atmosphere, soil, or ecosystem. Bioensors with sensitivity and specificity for the detection of uranium are highly demand. Nucleic acid enzymes (DNAzyme) with merits of high sensitivity and selectivity for targets as excellent molecular recognition elements are commonly used for uranium sensor development. In this perspective review, we summarize DNAzyme-based biosensors for the quantitative detection of uranyl ions by integrating with diverse signal outputting strategies, such as fluorescent, colorimetry, surface-enhanced Raman scattering, and electrochemistry. Different design methods, limit of detection, and practical applications are fully discussed. Finally, the challenges, potential solutions, and future prospects of such DNAzyme-based sensors are also presented.

【 授权许可】

Unknown