Cyanobacteria and microalgae bioactive compounds in skin-ageing: potential to restore extracellular matrix filling and overcome hyperpigmentation

Journal of Enzyme Inhibition and Medicinal Chemistry

Graciliana Lopes¹  Rosário Martins¹  Vitor Vasconcelos¹  Janaína Morone¹  Rita Favas¹ 

[1] CIIMAR/CIMAR, Interdisciplinary Centre of Marine and Environmental Research;

关键词: skin ageing;    matrix metalloproteinases;    collagenase;    elastase;    hyaluronidase;    hyperpigmentation;   

DOI  :  10.1080/14756366.2021.1960830

来源: DOAJ

【 摘 要 】

As the largest organ in human body, skin acts as a physicochemical barrier, offering protection against harmful environmental stressors, such as chemicals, pathogens, temperature and radiation. Nonetheless, skins prominence goes further, with a significant psychosocial role in an increasingly ageing population. Prompted by consumers’ concern regarding skincare, cosmetic industry has been developing new formulas capable of lessening the most visible signs of ageing, including reduction in skin density and elasticity, wrinkling and hyperpigmentation. Allied to skincare is the rising importance set on natural products, sustainably obtained from less environmental impacting methods. Cyanobacteria and microalgae are adding importance in this field, given their ability to biosynthesize secondary metabolites with anti-ageing potential. In this review, we present an overview on the potential of cyanobacteria and microalgae compounds to overcome skin-ageing, essentially by exploring their effects on the metalloproteinases collagenase, elastase, gelatinase and hyaluronidase, and in other enzymes involved in the pigmentation process.

【 授权许可】

Unknown