The role of collagenase in emphysema

Respiratory Research

Jeanine D'Armiento¹  Robert Foronjy¹ 

[1] Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA

关键词: matrix metalloproteinases;    emphysema;    elastase;    collagenase;    collagen;   

Others  :  1227422
DOI  :  10.1186/rr85

 received in 2001-03-23, accepted in 2001-08-07,  发布年份 2001

【 摘 要 】

The extracellular matrix is essential for the integrity of the lung and when disrupted can lead to the architectural changes seen in emphysema. The etiology of emphysema is believed to be due to an imbalance in the proteases and antiproteases within the lung. Studies have focused on elastolytic enzymes as the primary agents in disease pathogenesis, however, recent data suggest that collagenases may also be involved in the destruction of lung tissue in emphysema. It is hoped that this expanded understanding of the pathophysiology of emphysema will lead to improved therapy in the treatment of the disease.

【 授权许可】

   
2001 BioMed Central Ltd

【 图 表 】

Figure 7.

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