Metabolic Stress Index Including Mitochondrial Biomarker for Noninvasive Diagnosis of Hepatic Steatosis

Frontiers in Endocrinology

Ji Hye Huh¹  Jang-Young Kim²  Kyu-Sang Park³  Jae Seung Chang³  Sang-Baek Koh⁴  Jhii-Hyun Ahn⁵  Samuel S. Lee⁶  Moon Young Kim⁸  Soon Koo Baik⁸  Seong Hee Kang⁸ 

[1] Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, South Korea;Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea;Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, South Korea;Department of Preventive Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea;Department of Radiology, Yonsei University Wonju College of Medicine, Wonju, South Korea;Liver Unit, University of Calgary Cumming School of Medicine, Calgary, AB, Canada;Mitohormesis Research Center, Yonsei University Wonju College of Medicine, Wonju, South Korea;Regeneration Medicine Research Center, Yonsei University Wonju College of Medicine, Wonju, South Korea;

关键词: mitochondria;    non-alcoholic fatty liver disease;    FGF21;    FGF19;    adiponectin-to-leptin ratio;    central obesity;   

DOI  :  10.3389/fendo.2022.896334

来源: DOAJ

【 摘 要 】

BackgroundMitochondrial dysfunction with oxidative stress contributes to nonalcoholic fatty liver disease (NAFLD) progression. We investigated the steatosis predictive efficacy of a novel non-invasive diagnostic panel using metabolic stress biomarkers.MethodsAltogether, 343 subjects who underwent magnetic resonance imaging-based liver examinations from a population-based general cohort, and 41 patients enrolled in a biopsy-evaluated NAFLD cohort, participated in the development and validation groups, respectively. Serologic stress biomarkers were quantitated by enzyme-linked immunosorbent assay.ResultsMultivariate regression showed that waist-to-hip ratio, fibroblast growth factor (FGF) 21, FGF19, adiponectin-to-leptin ratio, insulin, albumin, triglyceride, total-cholesterol, and alanine-aminotransferase were independent predictors of steatosis (rank-ordered by Wald). The area under receiver-operator characteristics curve [AUROC (95%CI)] of the metabolic stress index for steatosis (MSI-S) was 0.886 (0.85−0.92) and 0.825 (0.69−0.96) in development and validation groups, respectively. MSI-S had higher diagnostic accuracy (78.1%−81.1%) than other steatosis indices. MSI-S notably differentiated steatosis severities, while other indices showed less discrimination.ConclusionMSI-S, as a novel non-invasive index, based on mitochondrial stress biomarker FGF21 effectively predicted steatosis. Furthermore, MSI-S may increase the population that could be excluded from further evaluation, reducing unnecessary invasive investigations more effectively than other indices.

【 授权许可】

Unknown