Increased left prefrontal brain perfusion after MRI compatible tDCS attenuates momentary ruminative self-referential thoughts

Brain Stimulation

Andre R. Brunoni¹  Romain Duprat²  Jonathan Remue³  Guo-Rong Wu⁴  Rudi De Raedt⁵  Marie-Anne Vanderhasselt⁵  Chris Baeken⁶  Sara De Witte⁶  Ernst H.W. Koster⁶ 

[1]Corresponding author. Department of Psychiatry and Medical Psychology, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium.

[2]Department of Experimental Clinical and Health Psychology, Ghent University, Belgium

[3]Department of Psychiatry, University Hospital UZBrussel, Brussels, Belgium

[4]Faculty of Medicine and Pharmacy, Free University Brussels, Brussels, Belgium

[5]Ghent Experimental Psychiatry (GHEP) Lab, Ghent, Belgium

[6]Department of Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, Ghent, Belgium

关键词: ASL;    DLPFC;    OFC;    MRSI;    tDCS;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Transcranial direct current stimulation (tDCS) is a non-invasive electrical stimulation technique, assumed to influence cognition and emotional processing. Objective: However, it is unclear how tDCS influences spontaneous cognitive processes such as momentary self-referential thoughts on the neuronal level. Methods: Forty healthy female volunteers participated in a single session sham-controlled crossover tDCS study while being in the MRI scanner. We measured brain perfusion (arterial spin labeling) just before and just after tDCS. Before and after the stimulation procedure, participants were scored on mood (visual analogue scales) and on the Momentary Ruminative Self-focus Inventory (MRSI). We performed a 1.5 mA, 20-min, anodal left dorsolateral prefrontal cortex, cathodal right supraorbital stimulation. Results: One sham-controlled tDCS session did not result in subjective mood changes. However, as compared to before, MRSI scores significantly decreased only after active tDCS. Regression analysis revealed that this reduction in momentary ruminative self-referential thoughts was related to tDCS-related increases in left prefrontal cortical perfusion. tDCS decreased momentary self-referential thoughts, which was associated with increasing perfusion in the left prefrontal cortex. Conclusion: Our findings are in line with the hypothesis that tDCS of the DLPFC attenuates ruminative processes.

【 授权许可】

Unknown