Magnesium and Anti-phosphate Treatment with Bisphosphonates for Generalised Arterial Calcification of Infancy: A Case Report

JCRPE

Fatma Dursun¹  Heves Kırmızıbekmez¹  Gülcan Seymen Karabulut¹  Serçin Güven²  Betül Sözeri³  Tülay Atasoy Öztürk⁴  Sevinç Kalın⁴ 

[1] Ümraniye Training and Research Hospital, Clinic of Pediatric Endocrinology, İstanbul, Turkey;Ümraniye Training and Research Hospital, Clinic of Pediatric Nephrology, İstanbul, Turkey;Ümraniye Training and Research Hospital, Clinic of Pediatric Rheumatology, İstanbul, Turkey;Ümraniye Training and Research Hospital, Clinic of Radiology, İstanbul, Turkey;

关键词: Generalized arterial calcification;    infant;    treatment;    magnesium;    etidronate;   

DOI  :  10.4274/jcrpe.galenos.2018.2018.0204

来源: DOAJ

【 摘 要 】

Generalized arterial calcification of infancy (GACI) is a rare autosomal-recessive disorder, characterized by calcification of the internal elastic lamina, fibrotic myointimal proliferation of muscular arteries and resultant arterial stenosis. Treatment with bisphosphonates has been proposed as a means of reducing arterial calcifications in GACI patients, although there is no formalized treatment approach. The case reported here was a patient with severe GACI diagnosed at three months of age who had no response to bisphosphonate treatment, but clinically improved after the initiation of magnesium and anti-phosphate (using calcium carbonate) treatments. In patients unresponsive to bisphosphonate, magnesium and anti-phosphate treatment may be attempted.

【 授权许可】

Unknown