Oxidative Stress Is a Key Modulator in the Development of Nonalcoholic Fatty Liver Disease

Antioxidants

Yuanqiang Ma¹  Yoon-Seok Roh¹  Gyurim Lee¹  Su-Young Heo² 

[1] College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Korea;College of Veterinary Medicine, Jeonbuk National University, Jeonju 54896, Korea;

关键词: NAFLD;    oxidative stress;    ROS;    mitochondria;    ER stress;    peroxisome;   

DOI  :  10.3390/antiox11010091

来源: DOAJ

【 摘 要 】

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and scientific studies consistently report that NAFLD development can be accelerated by oxidative stress. Oxidative stress can induce the progression of NAFLD to NASH by stimulating Kupffer cells, hepatic stellate cells, and hepatocytes. Therefore, studies are underway to identify the role of antioxidants in the treatment of NAFLD. In this review, we have summarized the origins of reactive oxygen species (ROS) in cells, the relationship between ROS and NAFLD, and have discussed the use of antioxidants as therapeutic agents for NAFLD.

【 授权许可】

Unknown