期刊论文详细信息
Molecules
Gastroprotective Effect of Microencapsulated Myrtus communis Essential Oil against Ethanol/HCl-Induced Acute Gastric Lesions
Susana M. Cardoso1  Raja Serairi Beji2  Rim Ben Mansour2  Hanen Wasli2  Wided Megdiche-Ksouri2  Riadh Ksouri2  Sami Zekri3 
[1] LAQV-REQUIMTE & Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal;Laboratory of Aromatic and Medicinal Plants, Centre of Biotechnology of Borj-Cedria, BP 901, Hammam-Lif 2050, Tunisia;USCR, Unité de Services Communs pour la Recherche en Microscopie Electronique à Transmission, Faculté de Médecine de Tunis, Tunis 1029, Tunisia;
关键词: Myrtus communis;    essential oil;    microencapsulation;    spray drying;    gastroprotective activity;    anti-inflammatory;   
DOI  :  10.3390/molecules27051566
来源: DOAJ
【 摘 要 】

Myrtus communis L. essential oil (EO), mainly composed of myrtenyl acetate (30.6%), linalool (14.9%), α-pinene (11.10%) and 1,8-cineole or eucalyptol (9.9%), was microencapsulated with maltodextrin by emulsification and spray-drying, reaching a yield and efficiency of 43.7 and 48.7%, respectively. The microencapsulated myrtle EO (MMEO) was then evaluated regarding its gastroprotective activity in a model of ethanol/HCl-induced acute gastric ulcer in Wistar rats. Pretreatment with MMEO induced a remarkable inhibition of gastric lesions and acidity, correlated to high healing and protection percentages. Moreover, it exerted a potent anti-inflammatory effect on the gastric mucosa, counteracting EtOH-induced gastric lipoperoxidation and preventing the depletion of the antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Taken together, the gastroprotective action of encapsulated MMEO may be multi-factorial, and ascribable, at least in parts, to its anti-inflammatory and antioxidant properties.

【 授权许可】

Unknown   

  文献评价指标  
  下载次数:0次 浏览次数:0次