Intestinal absorption and distribution of naringin, hesperidin, and their metabolites in mice

Journal of Functional Foods

Erhu Li¹  Kaikai Li²  Xiao Guo²  Ailing Guo² 

[1] Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, Wuhan 430070, Hubei, China;College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, China;

关键词: Naringin;    Hesperidin;    Absorption;    Distribution;    Intestinal tissue;   

DOI  :  

来源: DOAJ

【 摘 要 】

In this study, an in vivo animal experiment was performed, to investigate the intestinal absorption and distribution of naringin, hesperidin, and their metabolites by using UPLC-ESI-MS/MS and HPLC-PDA analysis. The bioavailability of naringin or hesperidin in duodenum, jejunum, ileum, cecum, and colon was calculated. A total of 7 and 13 metabolites were found and tentatively identified in intestinal tissue after orally administered naringin and hesperidin in mice, respectively. Sulfates of naringin could be absorbed by ileum and cecum, de-glycosylation metabolites could be absorbed by duodenum, and phenolic acids could be absorbed by the cecum and colon. Sulfates of hesperidin could be absorbed by duodenum and ileum, de-glycosylation metabolites could be absorbed by cecum, and phenolic acids could be absorbed by ileum, cecum and colon. Jejunum did not absorb metabolites of naringin or hesperidin. Results could be beneficial for understanding the intestinal bioactivities of naringin and hesperidin.

【 授权许可】

Unknown