A Novel Voltametric Measurements of Beta Blocker Drug Propranolol on Glassy Carbon Electrode Modified with Carbon Black Nanoparticles

Materials

Beata Paczosa-Bator¹  Joanna Smajdor¹  Robert Piech¹  Anna Górska¹  Izabela Bargiel¹ 

[1] Department of Analytical Chemistry and Biochemistry, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Al. Mickiewicza, 30-059 Kraków, Poland;

关键词: propranolol;    carbon black;    Nafion;    voltammetry;    modified electrode;   

DOI  :  10.3390/ma14247582

来源: DOAJ

【 摘 要 】

A new voltametric method for highly sensitive propranolol (PROP) determination was developed. A glassy carbon electrode modified with a hybrid material made of carbon black (CB) and Nafion was used as the working electrode. The preconcentration potential and time were optimized (550 mV and 15 s), as well as the supporting electrolyte (0.1 mol L⁻¹ H₂SO₄). For 15 s preconcentration time, linearity was achieved in the range 0.5–3.5 μmol L⁻¹ and for 120 s in 0.02–0.14 μmol L⁻¹. Based on the conducted calibration (120 s preconcentration time) limit of detection (LOD) was calculated and was equal to 7 nmol L⁻¹. To verify the usefulness of the developed method, propranolol determination was carried out in real samples (tablets and freeze-dried urine). Recoveries were calculated and were in the range 92–102%, suggesting that the method might be considered as accurate. The repeatability of the signal expressed as relative standard deviation (RSD) was equal to 1.5% (n = 9, PROP concentration 2.5 µmol L⁻¹). The obtained results proved that the developed method for propranolol determination might be successfully applied in routine laboratory practice.

【 授权许可】

Unknown