期刊论文详细信息
Journal of the Brazilian Chemical Society
Electrochemical behavior of Propranolol and its major metabolites, 4'-hydroxypropranolol and 4'-hydroxypropranolol Sulfate, on glassy carbon electrode
Silesian University of Technology, Gliwice, Poland1  Baranowska, Irena1  Koper, Marta1 
关键词: propranolol;    4'-hydroxypropranolol;    4'-hydroxypropranolol sulfate;    voltammetry;    glassy carbon electrode;   
DOI  :  10.1590/S0103-50532011000800025
学科分类:化学(综合)
来源: SciELO
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【 摘 要 】

The electrochemical behavior of propranolol (PRO) and its major metabolites was studied. Voltammetric measurements were made on glassy carbon electrode (GCE). All examined compounds were electrochemically oxidized. In all cases, a separation of oxidation peaks was observed, suggesting the possibility of simultaneous electroanalysis of propranolol and its metabolites. The linearity of the calibration curves was obtained for concentrations between 4.22×10-6-1.35×10-4 mol L-1 for PRO, 4.00×10-6-4.81×10-5 mol L-1 for 4'-hydroxypropranolol (4'OH PH) and 3.52×10-6-4.22×10-5 mol L-1 for 4'-hydroxypropranolol sulfate (4'OH PS). The described method is rapid and simple, and could be applied to determine the above mentioned compounds in biological samples. The obtained results were verified by ultra-high performance liquid chromatography (Ultra HPLC) method.

【 授权许可】

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