Learning and survival memory undergoing a permanent bilateral carotid ligation in rats

Acta Cirúrgica Brasileira

Guilherme Veras Mascena¹  Maria Cecília Santos Cavalcanti Melo¹  Diego Gadelha¹  Thárcia Kiara Beserra Oliveira¹  Carlos Teixeira Brandt² 

[1] Faculdade de Ciências Médicas de Campina Grande;Universidade Federal de Pernambuco;

关键词: Hypoxia-Ischemia, Brain;    Carotid Arteries;    Memory Disorders;    Rats;   

DOI  :  10.1590/S0102-86502013000200003

来源: DOAJ

【 摘 要 】

PURPOSE: To evaluate the effect of cerebral hypoxia-ischemia on memory and learning survival of rats submitted to permanent bilateral carotid ligation (PBCL). METHODS: Twenty-four survivors of PBCL were evaluated after 30 days with regard to memory and learning using a water survival maze. Twenty-three healthy rats were used as control group. The results were expressed by their means and standard error of the mean (SEM). p<0.05 was used for rejecting the null hypothesis. The study was approved by the Ethics Committee for animal investigation. RESULTS: The mortality rate for the surgery was 44.4%. The latency time to find the survival platform was higher in rats that underwent PBCL (Normal: 10.24 ± 1.85s - Study: 25.30 ± 4.69s - Mann - Whitney p=0.0388). Additionally, the type of swimming and the spatial stability of the studied rats on the survival platform were compromised in these animals. CONCLUSION: The permanent bilateral carotid ligation induces change in the learning and survival memory.

【 授权许可】

Unknown