Stability analysis of an artificial biomolecular oscillator with non-cooperative regulatory interactions

Journal of Biological Dynamics

Giulia Giordano¹  Christian Cuba Samaniego²  Elisa Franco²  Franco Blanchini³ 

[1] Lund University;University of California at Riverside;University of Udine;

关键词: Nonlinear systems;    nonlinear oscillations;    biological applications;    biochemistry;    molecular biology;   

DOI  :  10.1080/17513758.2016.1245790

来源: DOAJ

【 摘 要 】

Oscillators are essential to fuel autonomous behaviours in molecular systems. Artificial oscillators built with programmable biological molecules such as DNA and RNA are generally easy to build and tune, and can serve as timers for biological computation and regulation. We describe a new artificial nucleic acid biochemical reaction network, and we demonstrate its capacity to exhibit oscillatory solutions. This network can be built in vitro using nucleic acids and three bacteriophage enzymes, and has the potential to be implemented in cells. Numerical simulations suggest that oscillations occur in a realistic range of reaction rates and concentrations.

【 授权许可】

Unknown