External Validation of the Prognostic Value of an Immune-Associated Gene Panel for Clear Cell Renal Cell Carcinomas

Frontiers in Cell and Developmental Biology

Min Chen¹  Lei Wu²  Juntao Jiang²  Shan Hua³  Yongqing Zhang³  Fei Shi³  Zhihong Liu³  Zhiwen Xie³  Sheng Zhao⁴  Meng Liu⁵ 

[1] Department of General Surgery, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China;Department of Urology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China;Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Department of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China;Department of Urology, The Fifth People’s Hospital of Zunyi, Guizhou, China;

关键词: clear cell renal cell carcinomas;    immunotherapy;    immune gene;    prognosis panel;    nomogram;   

DOI  :  10.3389/fcell.2021.794840

来源: DOAJ

【 摘 要 】

Clear cell renal cell carcinomas (ccRCCs) are highly immune infiltrates, and many of them respond to immunotherapy with checkpoint inhibitors including anti-PD-L1 or anti-PD1 agents. However, the effect of immune genes on clinical outcomes in ccRCCs has not been fully studied. Here, we show in this study that an immune-associated gene panel has a prognostic value for clear cell renal cell carcinomas. We performed single-sample gene set enrichment analysis (ssGSEA) and cell type identification by estimating subsets of RNA transcripts (CIBERSORT) algorithms on patient-matched normal renal and RCC tissues to characterize two immunophenotypes and immunological characteristic subpopulations. Furthermore, LASSO Cox regression was applied to develop a novel prognosis-associated model for ccRCC patients based on an immune-gene panel. The results were verified by the Gene Expression Omnibus (GEO) dataset and coordinated with the clinicopathological characteristics of ccRCCs, along with genomic signatures. Finally, based on the above perspectives, we generated a nomogram with a high prognostic efficiency for ccRCC patients. Overall, this study offers a unique perspective that can contribute to improving the accuracy of prognosis prediction and treatment with immunotherapy.

【 授权许可】

Unknown