Volumetric brain abnormalities in adolescents with conduct disorder with and without attention deficit-hyperactivity disorder: a case control study

Middle East Current Psychiatry

Mohammad A. Seleem¹  Rasha El-Shafey²  Lamis T. Shahin³  Mina Rizkallah³  Noura M. Elkonaisy³  Yomna K. Marey³  Lina E. Abdel-Aziz³  Michael Baghdadi³ 

[1] Department of Psychiatry and Neurology, Faculty of Medicine, Tanta University;Department of Radiology, Faculty of Medicine, Tanta University;Tanta University Hospital;

关键词: Conduct;    ADHD;    Brain;    Volumetric;   

DOI  :  10.1186/s43045-020-00025-0

来源: DOAJ

【 摘 要 】

Abstract Background Conduct disorder (CD) is a prevalent psychiatric disorder in youth with heterogeneous presentations and hazardous outcomes on family and society. Identifying potential biological markers may help in better understanding and management of the problem. This work aims to explore the potential volumetric brain abnormalities in an Arab-Egyptian sample of conduct disordered youth with and without comorbid ADHD. A total of 27 subjects with conduct disorder, 14 of which also fulfilled the criteria of ADHD, in addition to twenty healthy subjects were recruited. A validated Arabic version of the Mini International Neuropsychiatric Interview for Children and Adolescents “M.I.N.I-Kid” was carried out. MRI acquisition was performed on 1.5 T Toshiba MRI scanner. Cortical reconstruction and automatic volumetric segmentation were performed with the Freesurfer image analysis suite. Results Youth with CD, with and without ADHD, showed significantly lower cortical thicknesses and smaller subcortical volumes in most of the hemispheric areas. When the two patient groups were compared, youth with CD + ADHD had significantly greater cortical thicknesses but smaller subcortical volumes as compared to youth with CD only. Conclusions Conduct disorder, comorbid with ADHD, might prove to be a distinct phenotypic entity with different biological substrates, and hence different needed management, from CD without comorbid ADHD.

【 授权许可】

Unknown