Poly(3-hydroxypropionate): Biosynthesis Pathways and Malonyl-CoA Biosensor Material Properties

Frontiers in Bioengineering and Biotechnology

Guangchao Sui¹  Hongyi Yang¹  Hongliang Cui¹  Albert Gyapong Aduhene¹  Changli Liu¹  Chengwei Liu¹ 

[1] College of Life Sciences, Northeast Forestry University, Harbin, China;Key Laboratory of Saline-Alkali Vegetation Ecology Restoration, Northeast Forestry University, Ministry of Education, Harbin, China;

关键词: poly(3-hydroxypropionate);    biosynthesis;    cell factory;    malonyl-CoA biosensor;    life cycle assessment;    material/physical property;   

DOI  :  10.3389/fbioe.2021.646995

来源: DOAJ

【 摘 要 】

Many single-use non-degradable plastics are a threat to life today, and several polyhydroxyalkanoates (PHAs) biopolymers have been developed in the bioplastic industry to place petrochemical-based plastics. One of such is the novel biomaterial poly(3-hydroxypropionate) [poly(3HP)] because of its biocompatibility, biodegradability, and high yield synthesis using engineered strains. To date, many bio-polymer-based functional composites have been developed to increase the value of raw microbial-biopolymers obtained from cheap sources. This review article broadly covers poly(3HP), a comprehensive summary of critical biosynthetic production pathways comparing the yields and titers achieved in different Microbial cell Factories. This article also provides extensive knowledge and highlights recent progress on biosensors’ use to optimize poly(3HP) production, some bacteria host adopted for production, chemical and physical properties, life cycle assessment for poly(3HP) production using corn oil as carbon source, and some essential medical applications of poly(3HP).

【 授权许可】

Unknown