Inflammation and atrial fibrillation: A comprehensive review

Journal of Arrhythmia

Christos A. Goudis¹  Tong Liu²  Gary Tse³  Panagiotis Korantzopoulos⁴  Konstantinos P. Letsas⁵  Nikolaos Fragakis⁶ 

[1] Cardiology Department Serres General Hospital Serres Greece;Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin China;Department of Medicine and Therapeutics Chinese University of Hong Kong Hong Kong China;First Department of Cardiology Medical School University of Ioannina Ioannina Greece;Second Department of Cardiology Laboratory of Cardiac Electrophysiology “Evangelismos” General Hospital of Athens Athens Greece;Third Department of Cardiology Hippokration Hospital Medical School Aristotle University of Thessaloniki Thessaloniki Greece;

关键词: anti‐inflammatory interventions;    atrial fibrillation;    atrial remodeling;    C‐reactive protein;    inflammation;   

DOI  :  10.1002/joa3.12077

来源: DOAJ

【 摘 要 】

Abstract Atrial fibrillation (AF) has different underlying substrates. Atrial remodeling involves electrophysiological and structural abnormalities that promote the development and perpetuation of AF. Experimental and clinical data indicate that inflammation is implicated in the pathophysiology of atrial remodeling. The mechanistic links between atrial remodeling and inflammation are complex while diverse underlying diseases and conditions may affect these pathways. Inflammatory markers have also been associated with AF development, recurrence, perpetuation, total AF burden as well as with thromboembolic complications. The development of specific anti‐inflammatory interventions in this setting seems to be challenging and complicated. Several agents with pleiotropic properties, including anti‐inflammatory, have been tested in experimental and clinical settings with variable results. This updated review provides a concise overview of all available data regarding the role of inflammation in AF including the predictive role of inflammatory markers. Also, current knowledge and future directions on anti‐inflammatory strategies are critically discussed.

【 授权许可】

Unknown