Exploring the Chemical Space of Macro- and Micro-Algae Using Comparative Metabolomics

Microorganisms

Laura Stucchi¹  Daniele Carettoni¹  MicheleS. Stanley²  Naomi Thomas²  Cecilia Rad-Menéndez²  KatherineR. Duncan³  Ahmed Tawfike³  Florent Magot³  RuAngelie Edrada-Ebel³  LouiseC. Young³  AlisonH. Hughes³ 

[1] Axxam SpA, Openzone, Bresso, 20091 Milan, Italy;Scottish Association for Marine Science, Scottish Marine Institute, Oban PA37 1QA, UK;Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK;

关键词: microalgae;    comparative metabolomics;    biotechnology;    bioactivity;    mass spectrometry;    microalgal metabolites;   

DOI  :  10.3390/microorganisms9020311

来源: DOAJ

【 摘 要 】

With more than 156,000 described species, eukaryotic algae (both macro- and micro-algae) are a rich source of biological diversity, however their chemical diversity remains largely unexplored. Specialised metabolites with promising biological activities have been widely reported for seaweeds, and more recently extracts from microalgae have exhibited activity in anticancer, antimicrobial, and antioxidant screens. However, we are still missing critical information on the distinction of chemical profiles between macro- and microalgae, as well as the chemical space these metabolites cover. This study has used an untargeted comparative metabolomics approach to explore the chemical diversity of seven seaweeds and 36 microalgal strains. A total of 1390 liquid chromatography-mass spectrometry (LC-MS) features were detected, representing small organic algal metabolites, with no overlap between the seaweeds and microalgae. An in-depth analysis of four Dunaliella tertiolecta strains shows that environmental factors may play a larger role than phylogeny when classifying their metabolomic profiles.

【 授权许可】

Unknown