Senescent skeletal cells cross-talk with synovial cells plays a key role in the pathogenesis of osteoarthritis

Arthritis Research & Therapy

Ri-Xu Liu¹  Jie Yang¹  Ning Liu¹  Zhen-Yan Li¹  Chong-Jie Wu¹  Zhen-Gang Zha¹  Yu-Kai Zeng¹  Huan-Tian Zhang¹  Wang Tang¹  Song-Wei Huan¹  Jun-Cheng Zhang¹  Ying Zhou¹ 

[1] Department of Bone and Joint Surgery, the First Affiliated Hospital, Jinan University;

关键词: Osteoarthritis;    Skeletal cells;    Cellular senescence;    SASP;    Targeted therapies;    Animal models;   

DOI  :  10.1186/s13075-022-02747-4

来源: DOAJ

【 摘 要 】

Abstract Osteoarthritis (OA) has been recognized as an age-related degenerative disease commonly seen in the elderly that affects the whole “organ” including cartilage, subchondral bone, synovium, and muscles. An increasing number of studies have suggested that the accumulation of senescent cells triggering by various stresses in the local joint contributes to the pathogenesis of age-related diseases including OA. In this review, we mainly focus on the role of the senescent skeletal cells (chondrocytes, osteoblasts, osteoclasts, osteocyte, and muscle cells) in initiating the development and progression of OA alone or through cross-talk with the macrophages/synovial cells. Accordingly, we summarize the current OA-targeted therapies based on the abovementioned theory, e.g., by eliminating senescent skeletal cells and/or inhibiting the senescence-associated secretory phenotype (SASP) that drives senescence. Furthermore, the existing animal models for the study of OA from the perspective of senescence are highlighted to fill the gap between basic research and clinical applications. Overall, in this review, we systematically assess the current understanding of cellular senescence in OA, which in turn might shed light on the stratified OA treatments.

【 授权许可】

Unknown