Lycium barbarum polysaccharides in ageing and its potential use for prevention and treatment of osteoarthritis: a systematic review

BMC Complementary Medicine and Therapies

Xinluan Wang¹  Hangkin Kong²  Manting Au³  Junguo Ni³  Chunyi Wen³ 

[1] Centre for Translational Medical Research and Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Science, Shen Zhen, China;Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Kowloon, Hong Kong;Department of Biomedical Engineering, Faculty of Engineering, Hong Kong Polytechnic University, Kowloon, Hong Kong;

关键词: Lycium Barbarum;    Reactive oxidative species;    Mitochondrial dysfunction;    Cellular senescence;    Osteoarthritis;   

DOI  :  10.1186/s12906-021-03385-0

来源: Springer

【 摘 要 】

BackgroundLycium barbarum polysaccharide (LBP), the most abundant functional component of wolfberry, is considered a potent antioxidant and an anti-ageing substance. This review aims to outline the hallmarks of ageing in the pathogenesis of osteoarthritis (OA), followed by the current understanding of the senolytic effect of LBP and its potential use in the prevention and treatment of OA. This will be discussed through the lens of molecular biology and herbal medicine.MethodsA literature search was performed from inception to March 2020 using following keywords: “Lycium barbarum polysaccharide”, “DNA damage”, antioxidant, anti-apoptosis, anti-inflammation, anti-ageing, osteoarthritis, chondrocytes, fibroblasts, osteoblasts, osteoclasts, and “bone mesenchymal stem cell”. The initial search yielded 2287 papers, from which 35 studies were selected for final analysis after screening for topic relevancy by the authors.ResultsIn literature different in vitro and in vivo ageing models are used to demonstrate LBP’s ability to reduce oxidative stress, restore mitochondrial function, mitigate DNA damage, and prevent cellular senescence. All the evidence hints that LBP theoretically attenuates senescent cell accumulation and suppresses the senescence-associated secretory phenotype as observed by the reduction in pro-inflammatory cytokines, like interleukin-1beta, and matrix-degrading enzymes, such as MMP-1 and MMP-13. However, there remains a lack of evidence on the disease-modifying effect of LBP in OA, although its chondroprotective, osteoprotective and anti-inflammatory effects were reported.ConclusionOur findings strongly support further investigations into the senolytic effect of LBP in the context of age-related OA.

【 授权许可】

CC BY