Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas

Genes and Diseases

Jiali Han¹  Hongji Dai¹  Ally-Khan Somani²  Xiaoli Zhang³  Sheng Liu⁴  Jun Wan⁵  Jingwu Xie⁵  Yuan Lin⁶ 

[1] Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA;Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA;School of Informatics and Computing, Indiana University – Purdue University at Indianapolis, Indianapolis, IN, 46202, USA;Department of Epidemiology and Biostatistics, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300000, PR China;Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA;Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA;

关键词: Basal cell carcinoma;    Gli1;    Hedgehog signaling;    PTCH1;    Squamous cell carcinoma;   

DOI  :  

来源: DOAJ

【 摘 要 】

The majority of non-melanoma skin cancer (NMSC) is cutaneous basal cell carcinoma (BCC) or squamous cell carcinoma (SCC), which are also called keratinocyte carcinomas, as both of them originate from keratinocytes. The incidence of keratinocyte carcinomas is over 5 million per year in the US, three-fold higher than the total incidence of all other types of cancer combined. While there are several reports on gene expression profiling of BCC and SCC, there are significant variations in the reported gene expression changes in different studies. One reason is that tumor-adjacent normal skin specimens were not included in many studies as matched controls. Furthermore, while numerous studies of skin stem cells in mouse models have been reported, their relevance to human skin cancer remains unknown. In this report, we analyzed gene expression profiles of paired specimens of keratinocyte carcinomas with their matched normal skin tissues as the control. Among several novel findings, we discovered a significant number of zinc finger encoding genes up-regulated in human BCC. In BCC, a novel link was found between hedgehog signaling, Wnt signaling, and the cilium. While the SCC cancer-stem-cell gene signature is shared between human and mouse SCCs, the hair follicle stem-cell signature of mice was not highly represented in human SCC. Differential gene expression (DEG) in human BCC shares gene signature with both bulge and epidermal stem cells. We have also determined that human BCCs and SCCs have distinct gene expression patterns, and some of them are not fully reflected in current mouse models.

【 授权许可】

Unknown