Recent Progress in Lipid Nanoparticles for Cancer Theranostics: Opportunity and Challenges

Pharmaceutics

Sarah I. Bukhari¹  Sultan Alshehri¹  Syed Sarim Imam¹  Wael A. Mahdi¹  Mohammad Zaki Ahmad²  Javed Ahmad²  Parameswara Rao Vuddanda³ 

[1] Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia;Department of Pharmaceutics, College of Pharmacy, Najran University, Najran 11001, Saudi Arabia;Research Centre for Topical Drug Delivery and Toxicology (TDDT), University of Hertfordshire, Hertfordshire AL10 9AB, UK;

关键词: cancer;    multi-drug resistance;    enhanced permeation and retention effect;    nanotherapeutics;    cancer theranostic;    clinical translation;   

DOI  :  10.3390/pharmaceutics13060840

来源: DOAJ

【 摘 要 】

Cancer is one of the major leading causes of mortality in the world. The implication of nanotherapeutics in cancer has garnered splendid attention owing to their capability to efficiently address various difficulties associated with conventional drug delivery systems such as non-specific biodistribution, poor efficacy, and the possibility of occurrence of multi-drug resistance. Amongst a plethora of nanocarriers for drugs, this review emphasized lipidic nanocarrier systems for delivering anticancer therapeutics because of their biocompatibility, safety, high drug loading and capability to simultaneously carrying imaging agent and ligands as well. Furthermore, to date, the lack of interaction between diagnosis and treatment has hampered the efforts of the nanotherapeutic approach alone to deal with cancer effectively. Therefore, a novel paradigm with concomitant imaging (with contrasting agents), targeting (with biomarkers), and anticancer agent being delivered in one lipidic nanocarrier system (as cancer theranostics) seems to be very promising in overcoming various hurdles in effective cancer treatment. The major obstacles that are supposed to be addressed by employing lipidic theranostic nanomedicine include nanomedicine reach to tumor cells, drug internalization in cancer cells for therapeutic intervention, off-site drug distribution, and uptake via the host immune system. A comprehensive account of recent research updates in the field of lipidic nanocarrier loaded with therapeutic and diagnostic agents is covered in the present article. Nevertheless, there are notable hurdles in the clinical translation of the lipidic theranostic nanomedicines, which are also highlighted in the present review along with plausible countermeasures.

【 授权许可】

Unknown