Toxins | |
Verotoxin-1 Treatment or Manipulation of its Receptor Globotriaosylceramide (Gb3) for Reversal of Multidrug Resistance to Cancer Chemotherapy | |
Parviz Behnam-Motlagh1  Andreas Tyler1  Kjell Grankvist1  | |
[1] Department of Medical Biosciences, Umeå University, S-901 85 Umea, Sweden; | |
关键词:
apoptosis;
cancer;
Gb3;
verotoxin-1;
multi-drug resistance;
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DOI : 10.3390/toxins2102467 | |
来源: mdpi | |
【 摘 要 】
A major problem with anti-cancer drug treatment is the development of acquired multidrug resistance (MDR) of the tumor cells. Verotoxin-1 (VT-1) exerts its cytotoxicity by targeting the globotriaosylceramide membrane receptor (Gb3), a glycolipid associated with multidrug resistance. Gb3 is overexpressed in many human tumors and tumor cell lines with inherent or acquired MDR. Gb3 is co-expressed and interplays with the membrane efflux transporter P-gp encoded by the
【 授权许可】
CC BY
© 2010 by the authors; licensee MDPI, Basel, Switzerland
【 预 览 】
Files | Size | Format | View |
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RO202003190052082ZK.pdf | 228KB | download |