Antiproliferative Activity and Induction of Apoptosis in PC-3 Cells by the Chalcone Cardamonin from Campomanesia adamantium (Myrtaceae) in a Bioactivity-Guided Study

Molecules

Aislan Cristina Rheder Fagundes Pascoal⁵  Carlos Augusto Ehrenfried²  Bego༚ Gimenez-Cassina Lopez⁵  Thiago Matos de Araujo⁴  Vinicius D’ávila Bitencourt Pascoal⁶  Rovilson Gilioli¹  Gabriel Forato Anhê⁴  Ana Lྫྷia Tasca Goes Ruiz³  João Ernesto de Carvalho³  Maria Élida Alves Stefanello² 

[1] Multidisciplinary Center for Biological Research, Laboratory Animal Quality Control, State University of Campinas, l6095, Campinas 13083-877, São Paulo, Brazil; E-Mail:;Department of Chemistry, Federal University of Paraná, 19081, Curitiba 81531-990, Paraná, Brazil; E-Mails:;Division of Pharmacology and Toxicology, Multidisciplinary Center for Chemical, Biological and Agricultural, State University of Campinas, 6171, Campinas 13081-970, São Paulo, Brazil; E-Mails:;Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas 13083-887, São Paulo, Brazil; E-Mails:;Graduate Program in Biosciences and Technology of Bioactive Products, Pharmacy course, State University of Campinas, Campinas, 6109, São Paulo 13083-970, Brazil; E-Mails:;Faculty of Basic Sciences, Fluminense Federal University, Nova Friburgo 24020-420, Rio de Janeiro, Brazil; E-Mail:

关键词: Campomanesia adamantium;    Myrtaceae;    chalcone;    cardamonin;    apoptosis;    cancer;   

DOI  :  10.3390/molecules19021843

来源: mdpi

【 摘 要 】

The Myrtaceae family is a common source of medicines used in the treatment of numerous diseases in South America. In Brazil, fruits of the Campomanesia species are widely used to make liqueurs, juices and sweets, whereas leaves are traditionally employed as a medicine for dysentery, stomach problems, diarrhea, cystitis and urethritis. Ethanol extracts of Campomanesia adamantium (Myrtaceae) leaves and fruits were evaluated against prostate cancer cells (PC-3). The compound (2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one, cardamonin) was isolated from ethanol extracts of C. adamantium leaves in a bioactivity-guided study and quantified by UPLC-MS/MS. In vitro studies showed that the isolated chalcone cardamonin inhibited prostate cancer cell proliferation and decreased the expression of NFkB1. Moreover, analysis by flow cytometry showed that this compound induced DNA fragmentation, suggesting an effect on apoptosis induction in the PC-3 cell line.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.