The prognostic utility of plasma osteopontin in CAP patients

Egyptian Journal of Chest Disease and Tuberculosis

Ibrahim S. Ibrahim¹  Ahmed Sh. Mohamed¹  Ragia S. Sharshar²  Amira Y. Abd El-Naby³ 

[1] Chest Department, Faculty of Medicine, Tanta University, Tanta, Egypt;Chest Department, Tanta University, Tanta, Egypt;Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt;

关键词: Community acquired pneumonia;    Severity indices;    Osteopontin;   

DOI  :  10.1016/j.ejcdt.2017.10.010

来源: DOAJ

【 摘 要 】

Background: Osteopontin (OPN) is a soluble cytokine glycoprotein widely expressed in many benign and malignant conditions. Purpose of study: was to investigate role of plasma OPN as new biomarker affects prognosis in CAP. Methodology: study was done on 50 subjects divided into 2 groups each 25, CAP (group I), healthy controls (group II). Plasma OPN levels were measured on initial hospitalization and after 3 days of treatment and correlated to severity of CAP by CRP and CURB-65. We concluded that: plasma levels of OPN is increased in pneumonia patients than in healthy controls also before than after 3 days of treatment of CAP. OPN levels significantly correlated with CURB-65 scores but not with CRP levels. Thus, OPN can be used as a novel additional marker, reflecting severity and response to treatment in CAP.

【 授权许可】

Unknown