Bisphenol A Alters the Energy Metabolism of Stromal Cells and Could Promote Bladder Cancer Progression

Cancers

Ève Pellerin¹  Stéphane Bolduc¹  Stéphane Chabaud¹  Martin Pelletier²  Frédéric Pouliot³ 

[1] Centre de Recherche en Organogénèse Expérimentale/LOEX, Regenerative Medicine Division, CHU de Québec-Université Laval Research Center, Québec, QC G1J 1Z4, Canada;Infectious and Immune Disease Division, CHU de Québec-Université Laval Research Center, Québec, QC G1V 4G2, Canada;Oncology Division, CHU de Québec-Université Laval Research Center, Québec, QC G1R 2J6, Canada;

关键词: bisphenol A;    cancer-associated fibroblasts;    bladder cancer;    metabolism;    glycolysis;   

DOI  :  10.3390/cancers13215461

来源: DOAJ

【 摘 要 】

Bisphenol A (BPA) is an endocrine-disrupting molecule used in plastics. Through its release in food and the environment, BPA can be found in humans and is mostly excreted in urine. The bladder is therefore continuously exposed to this compound. BPA can bind to multiple cell receptors involved in proliferation, migration and invasion pathways, and exposure to BPA is associated with cancer progression. Considering the physiological concentrations of BPA in urine, we tested the effect of nanomolar concentrations of BPA on the metabolism of bladder fibroblasts and cancer-associated fibroblasts (CAFs). Our results show that BPA led to a decreased metabolism in fibroblasts, which could alter the extracellular matrix. Furthermore, CAF induction triggered a metabolic switch, similar to the Warburg effect described in cancer cells. Additionally, we demonstrated that nanomolar concentrations of BPA could exacerbate this metabolic switch observed in CAFs via an increased glycolytic metabolism, leading to greater acidification of the extracellular environment. These findings suggest that chronic exposure to BPA could promote cancer progression through an alteration of the metabolism of stromal cells.

【 授权许可】

Unknown