Extraction Optimization of Mucilage from Seeds of Mimosa pudica by Response Surface Methodology

Polymers

Nasser F. Alotaibi¹  Mervat A. Elsherif¹  Hasan Ejaz²  Kashaf Junaid²  Syed Nasir Abbas Bukhari³  Muhammad Tayyab⁴  Arshad Ali⁵  Muhammad Ajaz Hussain⁵ 

[1] Chemistry Department, College of Science, Jouf University, Sakaka 72388, Saudi Arabia;Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi Arabia;Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72388, Saudi Arabia;Department of Pharmacy, Quaid-i-Azam University, Islamabad 45320, Pakistan;Institute of Chemistry, University of Sargodha, Sargodha 40100, Pakistan;

关键词: Mimosa pudica mucilage;    extraction optimization;    Box-Behnken design;    response surface methodology;    pH-responsive on–off switching;    zero-order release;   

DOI  :  10.3390/polym14091904

来源: DOAJ

【 摘 要 】

Mimosa pudica seed mucilage (MPM) is composed of glucuronoxylan, which is a swellable, pH-responsive and non-toxic biomaterial. Herein, we aimed to extract MPM from M. pudica seeds (MP seeds) to ascertain optimization of extraction conditions to get highest yield by response surface methodology, via Box-Behnken design (RSM-BBD). MPM was extracted from MP seeds by a hot water extraction method. The effects of four different parameters on the extraction yield of MPM were evaluated: pH of the extraction medium (1–10), seed/water contact time (1–12 h), the temperature of extraction medium (30–90 °C), and seed/water ratio (1:5–1:35 w/v). The maximum yield of MPM obtained by Design-Expert software was 10.66% (10.66 g/100 g) at pH 7, seed/water contact time of 6 h, extraction temperature of 50 °C, and seed/water ratio of 1:20 w/v. The p values of ANOVA were found to be less than 0.0001, which indicated that the extraction yield of MPM was significantly affected by all the study parameters. The results revealed that pH and extraction temperature were the most significant factors affecting the yield of MPM. MPM in compressed tablet form showed pH-responsive on–off switching behavior at pH 7.4 and 1.2 in a reversible manner. MPM in compressed tablet form sustained the release of itopride for 16 h following a super case-II transport mechanism and zero-order release kinetics.

【 授权许可】

Unknown