Aurora kinases orchestrate mitosis; who are the players?

Biomolecular Concepts

Molla Annie¹ 

[1] INSERM, U823, Centre de Recherche Albert Bonniot, Mécanisme d'assemblage et de régulation de l'appareil génétique, La Tronche, F-38706 France;

关键词: aurora kinase;    aurora-a kinase;    aurora-b kinase;    chromosomal passenger complex;    cytokinesis;    mitosis;    mitotic spindle;   

DOI  :  10.1515/bmc.2010.014

来源: DOAJ

【 摘 要 】

The Aurora are a conserved family of serine/threonine kinases with essential functions in cell division. In mitosis, Aurora kinases are required for chromosome segregation, condensation and orientation in the metaphase plate, spindle assembly, and the completion of cytokinesis. This review presents the Aurora kinases, their partners and how their interactions impact on the different mitotic functions.

【 授权许可】

Unknown