2-(2-Phenylethyl)chromone Derivatives of Agarwood Originating from Gyrinops salicifolia

Molecules

Hang Shao¹  Guo-Peng Zhu¹  Cui-Juan Gai²  Wei Li²  Hao-Fu Dai²  Wen-Hua Dong²  Wen-Li Mei² 

[1] Horticultural and Garden College, Hainan University, Haikou 570228, Hainan, China;Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China;

关键词: 2-(2-phenylethyl)chromone derivative;    2-(2-phenylethenyl)chromone derivative;    agarwood;    Gyrinops salicifolia;    cytotoxicity;   

DOI  :  10.3390/molecules21101313

来源: DOAJ

【 摘 要 】

Three new2-(2-phenylethyl)chromone derivatives (1–3) and a new2-(2-phenylethenyl)chromone derivative (4), together with two known 2-(2-phenylethyl)chromone derivatives (5–6), were isolated from agarwood originating from Gyrinops salicifolia Ridl. The structures of compounds 1–4 were elucidated by comprehensive spectroscopic techniques (UV, IR, 1D and 2D-NMR) and MS analysis, as well as by comparison with the literature. Compounds 1, 2, and 5 showed moderate cytotoxicity against human tumor K562, BEL-7402, and SGC-7901 cell lines with IC50 values of 5.76 to 20.1 µM.

【 授权许可】

Unknown