Data supporting the effects of xanthine derivative KMUP-3 on vascular smooth muscle cell calcification and abdominal aortic aneurysm in mice

Data in Brief

Jong-Hau Hsu¹  Ching-Wen Chang¹  Jwu-Lai Yeh²  Chung-Pin Liu²  Hua-Lin Wu³  Fang-Tzu Lee⁴  Cheng-Hsiang Kuo⁵  Chao-Han Lai⁵ 

[1] Cardiovascular Research Center, National Cheng Kung University, Tainan, Taiwan;Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan;Cardiovascular Research Center, National Cheng Kung University, Tainan, Taiwan;Department of Pharmacology, School of Medicine, College of Medicine, Kaohsiung Medical University, 100 Shih-Chuan First Road, Kaohsiung, Taiwan;Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan;

关键词: Xanthine derivative KMUP-3;    Abdominal aortic aneurysm;    In vitro calcification;    Vascular smooth muscle cell;    Phenotypic switch;    Apoptosis;   

DOI  :  

来源: DOAJ

【 摘 要 】

No pharmacotherapy in the clinical setting has been available to alter the natural history of abdominal aortic aneurysm (AAA). Targeting vascular smooth muscle cell (VSMC) dysfunction during the pathogenesis of AAA, including phenotypic switch and apoptosis, could be a potential strategy to limit AAA growth. Here, we provide additional information regarding materials, methods and data related to our recent study published in Atherosclerosis [1]. The therapeutic potential of a self-developed xanthine derivative KMUP-3 was evaluated in VSMC calcification and abdominal aortic aneurysm (AAA). In vitro VSMC calcification was induced using β-glycerophosphate, and AAA was induced using angiotensin II infusion for 4 weeks in apolipoprotein E-deficient mice. The data contained in this article support the effects of KMUP-3 on VSMC calcification and AAA.

【 授权许可】

Unknown