PDGF induces osteoprotegerin expression in vascular smooth muscle cells by multiple signal pathways

FEBS Letters

Myles, David¹  Zhang, Jifeng¹  Cao, Xu²  Chen, Yuqing E¹  Du, Jie³  Fu, Mingui¹  Zhu, Xiaojun¹ 

[1] Cardiovascular Research Institute, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310, USA;Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA;Cardiovascular Division, Kansas University Medical Center, Kansas City, KS 66160, USA

关键词: Osteoprotegerin;    Platelet-derived growth factor;    Gene expression;    Signaling pathway;    Vascular smooth muscle cell;   

DOI  :  10.1016/S0014-5793(02)02872-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Osteoprotegerin (OPG) is a key regulator of osteoclastogenesis. Recent reports suggest that OPG may function as a protector of arterial calcification and survival of endothelial cells. However, the role and expression of OPG in vascular wall is unclear. Here we report that OPG was highly expressed in vascular smooth muscle cells (VSMC) but not in endothelial cells. Platelet-derived growth factor (PDGF), basic fibroblast growth factor, angiotensin II, tumor necrosis factor α and interleukin-1β upregulated OPG expression in VSMC. Moreover, inhibition of phosphatidylinositol 3-kinase/Akt or P38-signal pathway abrogated PDGF-induced OPG expression. Our results suggest that OPG may be an important determinant of vascular homeostasis.

【 授权许可】

Unknown