Advances of immune checkpoints in colorectal cancer treatment

Biomedicine & Pharmacotherapy

Yidan Ren¹  Yuli Wang²  Chuanxin Wang³  Qin Wang³  Yun-shan Wang³  Lutao Du³  Xiaoyan Liu³  Abakundana Nsenga Ariston Gabrie³  Qinlian Jiao³ 

[1] International Biotechnology R&D Center, Shandong University School of Ocean, 180 Wenhua Xi Road, Weihai, Shandong 264209, China;Department of Anesthesiology, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan 250012, China;Department of Clinical Laboratory, The Second Hospital of Shandong University, 247 Beiyuan Street, Jinan 250033, Shandong, China;

关键词: Colorectal cancer;    Immunotherapy;    Immune checkpoints;   

DOI  :  

来源: DOAJ

【 摘 要 】

Colorectal cancer (CRC) is a malignant gastrointestinal cancer that seriously threatens human health. Its morbidity and mortality are in the forefront of tumors. Chemotherapy and radiotherapy play an important role in the treatment of CRC, which can improve the survival time and quality of life of patients, but the treatment progress is slow, and the treatment effect is not satisfactory. In recent years, immunotherapy has been a new direction in the field of colorectal cancer treatment after radiotherapy, chemotherapy and targeted therapy. Immune checkpoints play a vital role in the immunotherapy of cancer, and take part in the immune escape of cancer, which is closely related to the occurrence and development of cancer. This article reviews the research progress of immune checkpoints and their blockers in the field of CRC, in order to help better use of the immune system to treat cancer.

【 授权许可】

Unknown