Fate of Biodegradable Engineered Nanoparticles Used in Veterinary Medicine as Delivery Systems from a One Health Perspective

Molecules

CristinaM. Sabliov¹  CarlosE. Astete¹  JasonC. White²  Constantin Cerbu³  Melanie Kah⁴ 

[1] Biological and Agricultural Engineering Department, Louisiana State University and LSU Agricultural Center, Baton Rouge, LA 70803, USA;Connecticut Agricultural Experiment Station, New Haven, CT 06511, USA;Department of Infectious Diseases, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania;School of Environment, The University of Auckland, Auckland 1010, New Zealand;

关键词: nanoparticles;    veterinary medicine;    one health;    antibiotics;    hormones;    vaccines;   

DOI  :  10.3390/molecules26030523

来源: DOAJ

【 摘 要 】

The field of veterinary medicine needs new solutions to address the current challenges of antibiotic resistance and the need for increased animal production. In response, a multitude of delivery systems have been developed in the last 20 years in the form of engineered nanoparticles (ENPs), a subclass of which are polymeric, biodegradable ENPs, that are biocompatible and biodegradable (pbENPs). These platforms have been developed to deliver cargo, such as antibiotics, vaccines, and hormones, and in general, have been shown to be beneficial in many regards, particularly when comparing the efficacy of the delivered drugs to that of the conventional drug applications. However, the fate of pbENPs developed for veterinary applications is poorly understood. pbENPs undergo biotransformation as they are transferred from one ecosystem to another, and these transformations greatly affect their impact on health and the environment. This review addresses nanoparticle fate and impact on animals, the environment, and humans from a One Health perspective.

【 授权许可】

Unknown