Endothelialization of Novel Magnesium-Rare Earth Alloys with Fluoride and Collagen Coating

International Journal of Molecular Sciences

Donghui Zhu¹  Nan Zhao¹  Benjamin Workman¹ 

[1] Department of Chemical, Biological and Bio-Engineering, NSF Engineering ResearchCenter-Revolutionizing Metallic Biomaterials, North Carolina Agricultural andTechnical State University, Greensboro, NC 27411, USA;

关键词: magnesium;    rare earth elements;    corrosion;    surface coating;    biocompatibility;   

DOI  :  10.3390/ijms15045263

来源: DOAJ

【 摘 要 】

Magnesium (Mg) alloys are promising scaffolds for the next generation of cardiovascular stents because of their better biocompatibility and biodegradation compared to traditional metals. However, insufficient mechanical strength and high degradation rate are still the two main limitations for Mg materials. Hydrofluoric acid (HF) treatment and collagen coating were used in this research to improve the endothelialization of two rare earth-based Mg alloys. Results demonstrated that a nanoporous film structure of fluoride with thickness of ~20 µm was formed on the Mg material surface, which improved the corrosion resistance. Primary human coronary artery endothelial cells (HCAECs) had much better attachment, spreading, growth and proliferation (the process of endothelialization) on HF-treated Mg materials compared to bare- or collagen-coated ones.

【 授权许可】

Unknown