In Vitro Corrosion and Cytocompatibility of ZK60 Magnesium Alloy Coated with Hydroxyapatite by a Simple Chemical Conversion Process for Orthopedic Applications

International Journal of Molecular Sciences

Bing Wang³  Ping Huang²  Caiwen Ou¹  Kaikai Li²  Biao Yan² 

[1] Key Laboratory of Construction and Detection of Guangdong Province, Southern Medical University, No.1023, Shatai Nan Road, Guangzhou 510515, China; E-Mail:;Shanghai Key Laboratory of D&A for Metal-Functional Materials, Tongji University, Shanghai 201804, China; E-Mails:;Affiliated Tongji Hospital, Tongji University, Shanghai 201804, China; E-Mail:

关键词: magnesium;    hydroxyapatite;    coating;    corrosion;    biocompatibility;   

DOI  :  10.3390/ijms141223614

来源: mdpi

【 摘 要 】

Magnesium and its alloys—a new class of degradable metallic biomaterials—are being increasingly investigated as a promising alternative for medical implant and device applications due to their advantageous mechanical and biological properties. However, the high corrosion rate in physiological environments prevents the clinical application of Mg-based materials. Therefore, the objective of this study was to develop a hydroxyapatite (HA) coating on ZK60 magnesium alloy substrates to mediate the rapid degradation of Mg while improving its cytocompatibility for orthopedic applications. A simple chemical conversion process was applied to prepare HA coating on ZK60 magnesium alloy. Surface morphology, elemental compositions, and crystal structures were characterized using scanning electron microscopy, energy dispersive spectroscopy, and X-ray diffraction, respectively. The corrosion properties of samples were investigated by immersion test and electrochemical test. Murine fibroblast L-929 cells were harvested and cultured with coated and non-coated ZK60 samples to determine cytocompatibility. The degradation results suggested that the HA coatings decreased the degradation of ZK60 alloy. No significant deterioration in compression strength was observed for all the uncoated and coated samples after 2 and 4 weeks’ immersion in simulated body fluid (SBF). Cytotoxicity test indicated that the coatings, especially HA coating, improved cytocompatibility of ZK60 alloy for L929 cells.

【 授权许可】

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