Echocardiographic epicardial fat thickness and immature granulocyte are novel inflammatory predictors of acute ischemic stroke: a prospective study

São Paulo Medical Journal

关键词: Ultrasonography;    Granulocytes;    Ischemic stroke;    Echocardiographic measurement;    Inflammation indicators;    Acute cerebrovascular event;   

DOI  :  10.1590/1516-3180.2021.0461.r1.16082021

来源: DOAJ

【 摘 要 】

ABSTRACTBACKGROUND: Acute ischemic stroke (AIS) is the most common type of stroke. Inflammation is the primary factor in the pathogenesis of atherosclerosis. Use of immature granulocytes (IGs) has been recommended as a new indicator of systemic inflammation. However, data on the association between echocardiographic epicardial fat tissue thickness (EFT) and IGs in patients with AIS are limited.OBJECTIVE: To evaluate the association between the presences of IGs, epicardial fat tissue and AIS.DESIGN AND SETTING: Prospective study in a tertiary-care university hospital in Antalya, Turkey.METHODS: Our study included 53 AIS patients and 41 healthy controls with age and gender compatibility. Blood samples and transthoracic echocardiography of all participants were compared.RESULTS: IG levels were significantly higher in patients with AIS than in controls (0.62 ± 0.36 versus 0.28 ± 0.02, P < 0.001). The mean EFT was 3.74 ± 0.61 mm in the control group and 6.33 ± 1.47 mm in the AIS patient group. EFT was significantly greater in AIS patients than in controls (P < 0.001). For the optimum cut-off value for IG (0.95), the area under the curve (AUC) was determined to be 0.840; sensitivity was determined to be 81.1% and specificity, 92.5%. For the optimum cut-off value for EFT (4.95 mm), the AUC was determined to be 0.953; sensitivity was determined to be 90.6% and specificity, 90%.CONCLUSIONS: IG and echocardiographic EFT are clinical markers that can be used to predict AIS risk.

【 授权许可】

Unknown