Emerging Potential of Exosomes on Adipogenic Differentiation of Mesenchymal Stem Cells

Frontiers in Cell and Developmental Biology

Di Miao¹  Xiang Li²  Shuling Bai³  Xiaohong Wang³  Xiaohong Tian³  Yuxuan Zhong³  Jun Fan³  Fanglin Wang³  Shoushuai Wang³ 

[1] China Medical University–The Queen’s University of Belfast Joint College–Combination, Shenyang, China;Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China;Department of Tissue Engineering, School of Fundamental Science, China Medical University, Shenyang, China;

关键词: exosomes;    mesenchymal stem cell;    adipogenic differentiation;    adipogenesis;    regenerative medicine;   

DOI  :  10.3389/fcell.2021.649552

来源: DOAJ

【 摘 要 】

The mesenchymal stem cells have multidirectional differentiation potential and can differentiate into adipocytes, osteoblasts, cartilage tissue, muscle cells and so on. The adipogenic differentiation of mesenchymal stem cells is of great significance for the construction of tissue-engineered fat and the treatment of soft tissue defects. Exosomes are nanoscale vesicles secreted by cells and widely exist in body fluids. They are mainly involved in cell communication processes and transferring cargo contents to recipient cells. In addition, exosomes can also promote tissue and organ regeneration. Recent studies have shown that various exosomes can influence the adipogenic differentiation of stem cells. In this review, the effects of exosomes on stem cell differentiation, especially on adipogenic differentiation, will be discussed, and the mechanisms and conclusions will be drawn. The main purpose of studying the role of these exosomes is to understand more comprehensively the influencing factors existing in the process of stem cell differentiation into adipocytes and provide a new idea in adipose tissue engineering research.

【 授权许可】

Unknown