Transglutaminases and Obesity in Humans: Association of F13A1 to Adipocyte Hypertrophy and Adipose Tissue Immune Response

International Journal of Molecular Sciences

Jaakko Kaprio¹  Mansi Arora²  MariT. Kaartinen²  Aila Rissanen³  KirsiH. Pietiläinen³  Sini Heinonen³ 

[1] Department of Public Health, University of Helsinki, 00100 Helsinki, Finland;Faculty of Medicine (Experimental Medicine), McGill University, Montreal, QC H3A 0J7, Canada;Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland;

关键词: Factor XIII-A;    F131A;    obesity;    weight gain;    adipocyte size;    inflammation;   

DOI  :  10.3390/ijms21218289

来源: DOAJ

【 摘 要 】

Transglutaminases TG2 and FXIII-A have recently been linked to adipose tissue biology and obesity, however, human studies for TG family members in adipocytes have not been conducted. In this study, we investigated the association of TGM family members to acquired weight gain in a rare set of monozygotic (MZ) twins discordant for body weight, i.e., heavy–lean twin pairs. We report that F13A1 is the only TGM family member showing significantly altered, higher expression in adipose tissue of the heavier twin. Our previous work linked adipocyte F13A1 to increased weight, body fat mass, adipocyte size, and pro-inflammatory pathways. Here, we explored further the link of F13A1 to adipocyte size in the MZ twins via a previously conducted TWA study that was further mined for genes that specifically associate to hypertrophic adipocytes. We report that differential expression of F13A1 (ΔHeavy–Lean) associated with 47 genes which were linked via gene enrichment analysis to immune response, leucocyte and neutrophil activation, as well as cytokine response and signaling. Our work brings further support to the role of F13A1 in the human adipose tissue pathology, suggesting a role in the cascade that links hypertrophic adipocytes with inflammation.

【 授权许可】

Unknown