Non-Coding RNAs in Kidney Diseases: The Long and Short of Them

International Journal of Molecular Sciences

Laurent Metzinger¹  Valérie Metzinger-Le Meuth¹  Eya Hamza¹  Cristina García-Caballero²  Juan Antonio Moreno²  Melania Guerrero-Hue²  Mercedes Vallejo-Mudarra²  Sandra Rayego-Mateos³ 

[1] HEMATIM UR 4666, C.U.R.S, Université de Picardie Jules Verne (UPJV), CEDEX 1, 80025 Amiens, France;Maimonides Biomedical Research Institute of Cordoba (IMIBIC), UGC Nephrology, Hospital Universitario Reina Sofía, 14004 Córdoba, Spain;Renal, Vascular and Diabetes Research Laboratory, IIS-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, 28040 Madrid, Spain;

关键词: non-coding RNA;    microRNA;    long non-coding RNA;    chronic kidney disease;    acute kidney disease;    IgA nephropathy;   

DOI  :  10.3390/ijms22116077

来源: DOAJ

【 摘 要 】

Recent progress in genomic research has highlighted the genome to be much more transcribed than expected. The formerly so-called junk DNA encodes a miscellaneous group of largely unknown RNA transcripts, which contain the long non-coding RNAs (lncRNAs) family. lncRNAs are instrumental in gene regulation. Moreover, understanding their biological roles in the physiopathology of many diseases, including renal, is a new challenge. lncRNAs regulate the effects of microRNAs (miRNA) on mRNA expression. Understanding the complex crosstalk between lncRNA–miRNA–mRNA is one of the main challenges of modern molecular biology. This review aims to summarize the role of lncRNA on kidney diseases, the molecular mechanisms involved, and their function as emerging prognostic biomarkers for both acute and chronic kidney diseases. Finally, we will also outline new therapeutic opportunities to diminish renal injury by targeting lncRNA with antisense oligonucleotides.

【 授权许可】

Unknown