Non-Coding RNAs in Primary Liver Cancer

Frontiers in Medicine

Michele Ghidini¹ 

关键词: non-coding RNA;    microRNA;    long non-coding RNA;    HCC;    liver cancer;   

DOI  :  10.3389/fmed.2015.00036

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

Hepatocellular carcinoma (HCC) is a primary malignancy of the liver with poor prognosis and limited therapeutic options. Over the past few years, many studies have evaluated the role of non-coding RNAs (ncRNAs) in hepatocarcinogenesis and tumor progression. ncRNAs were shown to have diagnostic, prognostic, and therapeutic potential in HCC. In this manuscript, we review the latest major discoveries concerning microRNAs and long ncRNAs in HCC pathogenesis, and discuss the potentials and the limitations for their use in clinical practice.

【 授权许可】

CC BY