Histone Lysine Methylation Modification and Its Role in Vascular Calcification

Frontiers in Endocrinology

Zhi-Ang Zhou¹  Xiao-Bo Liao¹  Feng Wu²  Xiao Lin³  Chang-Chun Li⁴  Muhammad Hasnain Ehsan Ullah⁴  Su-Kang Shan⁴  Bei Guo⁴  Ke-Xin Tang⁴  Yun-Yun Wu⁴  Li-Min Lei⁴  Feng Xu⁴  Fu-Xing-Zi Li⁴  Yi Wang⁴  Qiu-Shuang Xu⁴  Wen-Lu Ou-Yang⁴  Ling-Qing Yuan⁴  Ye-Chi Cao⁴  Jia-Yue Duan⁴  Ming-Hui Zheng⁴ 

[1] Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, China;Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, China;Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China;National Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, China;

关键词: epigenetics modification;    histone lysine methylation;    histone lysine methyltransferases (HKMTs);    vascular calcification;    signalling pathways;   

DOI  :  10.3389/fendo.2022.863708

来源: DOAJ

【 摘 要 】

Histone methylation is an epigenetic change mediated by histone methyltransferase, and has been connected to the beginning and progression of several diseases. The most common ailments that affect the elderly are cardiovascular and cerebrovascular disorders. They are the leading causes of death, and their incidence is linked to vascular calcification (VC). The key mechanism of VC is the transformation of vascular smooth muscle cells (VSMCs) into osteoblast-like phenotypes, which is a highly adjustable process involving a variety of complex pathophysiological processes, such as metabolic abnormalities, apoptosis, oxidative stress and signalling pathways. Many researchers have investigated the mechanism of VC and related targets for the prevention and treatment of cardiovascular and cerebrovascular diseases. Their findings revealed that histone lysine methylation modification may play a key role in the various stages of VC. As a result, a thorough examination of the role and mechanism of lysine methylation modification in physiological and pathological states is critical, not only for identifying specific molecular markers of VC and new therapeutic targets, but also for directing the development of new related drugs. Finally, we provide this review to discover the association between histone methylation modification and VC, as well as diverse approaches with which to investigate the pathophysiology of VC and prospective treatment possibilities.

【 授权许可】

Unknown